DPP-4, SGLT-2 inhibitors, GLP-1 agonist Medications Quiz

What is the primary mechanism of action for GLP-1 medications?

• They increase the absorption of nutrients in the gut.

• They bind to GLP-1 receptors found throughout the body.

• They block hunger signals from reaching the brain.

• They stimulate the production of digestive enzymes.

Answer explanation

GLP-1 medications bind to GLP-1 receptors found throughout the body, which is their primary mechanism of action.

Which of the following is NOT a benefit of GLP-1 medications beyond appetite suppression?

• They help regulate glucose levels.

• They improve conditions such as cardiovascular disease.

• They cause a complete lack of hunger followed by rebound hunger.

• They may improve memory and inflammation.

Answer explanation

GLP-1 medications do not cause a complete lack of hunger followed by rebound hunger, making this the correct choice as it is not a benefit beyond appetite suppression.

What is a common side effect of GLP-1 medications?

• High blood sugar levels.

• Increased heart rate.

• Nausea, vomiting, and diarrhea.

• Excessive weight gain.

Answer explanation

The correct side effect of GLP-1 medications is nausea, vomiting, and diarrhea, not high blood sugar levels, increased heart rate, or excessive weight gain.

GLP-1 medications are particularly beneficial for patients with which of the following conditions?

• High blood pressure.

• PCOS, insulin resistance, prediabetes, and diabetes.

• Common cold and flu.

• Bone fractures and osteoporosis.

Answer explanation

GLP-1 medications are particularly beneficial for patients with PCOS, insulin resistance, prediabetes, and diabetes, making this the correct choice.

How do GLP-1 medications affect a patient's eating pattern?

• They lead to overeating due to increased appetite.

• They cause patients to skip meals.

• They make patients take smaller portions because they feel full sooner.

• They have no impact on eating patterns.

Answer explanation

GLP-1 medications make patients take smaller portions because they feel full sooner, affecting their eating pattern.

What triggers pancreatic beta cells to produce and secrete more amylin, a hormone co-secreted with insulin?

• Hypoglycemia

• Hyperglycemia

• Insulin resistance

• Amyloid-beta (Aβ) interaction

Answer explanation

Pancreatic beta cells produce and secrete more amylin in response to hyperglycemia, as it helps regulate blood sugar levels alongside insulin.

Tags

NGSS.HS-LS1-3

What is a characteristic feature of type 2 diabetes related to amylin?

• Neurodegeneration in the brain

• Amylin aggregation forming amyloid deposits in the pancreas

• Cognitive impairment

• Increased insulin production

Answer explanation

The characteristic feature of type 2 diabetes related to amylin is amylin aggregation forming amyloid deposits in the pancreas.

Where can amylin aggregates also deposit in the body, contributing to Alzheimer's disease?

• In the liver

• In the pancreas

• In the brain's blood vessels and tissue

• In the kidney

Answer explanation

Amylin aggregates can also deposit in the brain's blood vessels and tissue, contributing to Alzheimer's disease.

How does the interaction between amylin and amyloid-beta (Aβ) contribute to Alzheimer's disease?

• By reducing insulin resistance

• By decreasing amylin production

• By accelerating amyloid plaque formation in the brain

• By improving cognitive function

Answer explanation

The interaction between amylin and amyloid-beta accelerates amyloid plaque formation in the brain, contributing to Alzheimer's disease.

What is the consequence of the presence of amylin aggregates in the brain?

• Improved heart health

• Neurodegeneration and cognitive impairment

• Lower blood sugar levels

• Decreased amyloid-beta plaque formation

Answer explanation

The consequence of the presence of amylin aggregates in the brain is neurodegeneration and cognitive impairment.