Renal Clearance MCQ

Which of the following properties is essential for a substance to be used in measuring the glomerular filtration rate (GFR)?

• • It must be synthesized by the tubule.

• • It must be reabsorbed.

• • It must not be metabolized by the tubule.

• • It should be secreted by the renal tubule.

Inulin is used to determine the GFR because it:

• • Is freely filtered at the renal corpuscle and not reabsorbed or secreted.

• • Is metabolized by the tubule.

• • Is synthesized by the tubule.

• • Has a high plasma concentration

Why does the clearance of creatinine slightly overestimate the GFR?

• • Creatinine is completely reabsorbed by the tubules.

• • Creatinine is not filtered at the renal corpuscle.

• • Creatinine is also secreted by the renal tubule.

• • Creatinine clearance is not proportional to muscle mass.

The effective renal plasma flow (ERPF) can be measured using the clearance of which substance?

• • Inulin

• • Glucose

• • Para-amino hippuric acid (PAH)

• • Urea

What indicates a substance is being reabsorbed if its renal clearance rate is compared to inulin?

• • The clearance rate is equal to that of inulin.

• • The clearance rate is greater than that of inulin.

• • The clearance rate is less than that of inulin.

• • The substance is not filtered at all.