T cell development

How many signals are required for naive Tcell activation?

• 1 signal

• 2 signals

• 3 signals

Answer explanation

1) antigen specific TCR engagement

2) contact with costimulatory ligands

3) sytokines directing T cell differentiation into distinct effector cell types

Co-stimulatory signals are required for optimal T cell activation and proliferation

• True

• False

antigen-specific TCR engagement

• signal 1

• signal 2

• signal 3

contact with co-stimulatory ligands

• signal 1

• signal 2

• signal 3

cytokines directing T cell differentiation into distinct effector cell types

• signal 1

• signal 2

• signal 3

Answer explanation

Does T cell activation require cell-cell contact?

• yes

• no

The interface between the APC and the naive T cell.

• Immunologic synapse

• not this

Immunological synapse is initiated by

• TCR recognition of MHC

• not this