SARS-CoV-2 Quiz

What does SARS-CoV-2 use to enter target cells?

• Polyclonal antibodies

• ACE2

• Cryo-EM structures

• Vaccine designs

Which of the following statements is true regarding the affinity of SARS-CoV-2 and SARS-CoV to ACE2?

• SARS-CoV-2 has a higher affinity to ACE2 than SARS-CoV.

• SARS-CoV has a higher affinity to ACE2 than SARS-CoV-2.

• SARS-CoV-2 and SARS-CoV bind with similar affinities to ACE2.

• Neither SARS-CoV-2 nor SARS-CoV can bind to ACE2.

What is the significance of the structures of SARS-CoV-2 spike glycoprotein in the context of vaccine and therapeutic design?

• They indicate the ineffectiveness of current vaccines.

• They provide a blueprint for the design of vaccines and therapeutics.

• They show that SARS-CoV-2 cannot be targeted by vaccines.

• They demonstrate the stability of the spike glycoprotein in all environments.

How can SARS-CoV polyclonal antibodies affect SARS-CoV-2?

• They enhance the entry of SARS-CoV-2 into cells.

• They have no effect on SARS-CoV-2.

• They inhibit SARS-CoV-2 spike-mediated entry into cells.

• They increase the affinity of SARS-CoV-2 to ACE2.

What is the main target of antibodies against SARS-CoV-2 according to the article?

• The membrane protein

• The envelope protein

• The spike (S) glycoprotein

• The nucleocapsid protein

Which domain of the SARS-CoV-2 spike glycoprotein binds with human ACE2 receptors?

• The S1 subunit

• The S2 subunit

• The membrane-binding domain

• The nucleocapsid-binding domain

What does the article suggest about the possibility of creating vaccines that elicit cross-neutralizing antibodies against SARS-CoV-2?

• It is not possible due to rapid mutation

• It is highly unlikely due to the virus's structure

• It is possible by targeting conserved SARS-CoV-2 epitopes

• It is only possible with live attenuated vaccines

As of the date of the article, how many confirmed cases of COVID-19 were there globally?

• Over 90,000

• Over 3,000,000

• Over 8,098

• Over 2,494

Which animal is unequivocally considered the reservoir host for SARS-CoV-2?

• Bats

• Pangolins

• Camels

• Civets

What is the function of the S2 subunit of the SARS-CoV-2 spike glycoprotein?

• It binds to the human ACE2 receptor.

• It facilitates membrane fusion.

• It harbors the receptor-binding domain.

• It is processed during biogenesis.