PSH_MM

It is the most common symptom of myeloma

• Bone Pain

• anemia

• Renal failure

• bleeding

Which of the following is a myeloma defining event

• hypercalcemia >10mg/dl

• Creatinine >2mg/dL or Crea clearance <40mL/min

• Anemia <8mg/dL

• One or more osteblastic lesions

In diagnosis of multiple myeloma how marrow plasma cells should be present?

• >10%

• >5%

• >15%

• >20%

The following are feature responsible for higher risk of progression from smoldering MM to multiple myeloma, EXCEPT?

• Plasmacytosis >10%

• Abnormal kappa/lambda free light chain ratio

• M protein >3g/dL

• Non-IgG subtype

What IgG myelomas has the highest tendency to form both concentration and temperature dependent aggregates leading to hyperviscosity and cold agglutination at lower serum concentration?

• IgG1

• IgG3

• IgG2

• IgG4

True or False

In Multiple Myeloma the increased in Alkaline Phosphatase is due to osteoblastic activity

• True

• False

Answer explanation

Alk Phos in MM is usually normal even in extensive bone involvement due to absence of osteoblastic activity