Neuromuscular Jun Dr. Jones Neuro Exam 1

Which of the following neurons come out of the spinal cord and are EXCITATORY?

• beta motor neuron

• alpha motor neuron

• delta motor neuron

• gamma motor neuron

Acetylcholine binds to which inotropic receptors causing Na+ coming into our muscle cells?

• nicotinic

• muscarinic

• beta 2

• alpha 1

Where do action potentials that began out of the membrane are going to propagate down to invaginated membranes to signal Ca+ release from the sarcoplasmic reticulum?

• Synaptic terminal

• T tubule

• Sarcomere

• Mitochondrion

Where do we store Ca++?

• T-tubule

• Sarcoplasmic reticulum

• Sarcomere

• Plasma membrane

Which of the following causes the opening of the Ryanodine receptor due to depolarization allowing Ca+ come out to the cytoplasm of muscles cells causing contraction?

• Dihydropyridine receptor (DHP)

• Tyrosine

• Tryptophan

• Glycine

A 15 years old patient arrive at the ER with symptoms of generalized weakness, eyebrow droop and also in the corner of the mouth. The patient has a clinical history of diagnosed Myasthenia Gravis which is an autoimmune disease.

Which of the following mostly occur in this disease?

• Increase number of nAchRs on the motor endplate by autoimmune antibodies

• Decrease/destruction in the nAchRs on the motor endplate by autoimmune antibodies

• Overproduction of nAchRs on the motor endplate by autoimmune antibodies

• Decrease in the dopamine receptors on the motor endplate by autoimmune antibodies

A 21 years old patient arrive at the ER with signs like having difficulty raising arms and proximal muscles in lower extremities have been affected. The patient has a clinical history of diagnosed small cell lung cancer. Patient suffers from Lambert Eaton Syndrome.

Which of the following mostly occur in this autoimmune disease?

• autoimmune antibodies destroy the voltage gated Na+ channels in the pre synaptic alpha motor neuron affecting NMJ

• autoimmune antibodies destroy the voltage gated Ca++ channels in the pre synaptic alpha motor neuron affecting NMJ

• autoimmune antibodies destroy the voltage gated Na+ channels in the post synaptic alpha motor neuron affecting NMJ

• autoimmune antibodies destroy the voltage gated K+ channels in the pre synaptic alpha motor neuron affecting NMJ

Which of the following release neurotransmitters into the smooth muscle?

• T-tubule

• Varicosities

• Sarcomere

• Mitochondrion