Med chem: cholinomimetics exam 3

Single protein with 7 transmembrane domains.

• nicotinic receptor

• muscarinic receptor

Which are G protein coupled receptors?

• nicotinic receptors

• muscarinic receptors

Which is the active form?

• aBy GDP

• a GTP

Which is inactive form?

• aBy GDP

• a GTP

The a subunit of the G protein has intrinsic GTPase activity and can hydrolyze GTP to GDP itself to inactive itself.

• True

• False

When is the a subunit associated with the beta gamma units?

• active state

• resting state

When is the alpha subunit dissociated from the beta gamma subunits?

• active

• resting

increases adenylate cyclase activity, increases cAMP, increases protein kinase A that can enter the nucleus for transcription activity.

• Gi

• Gs

• Gq

Gs

• Beta adrenergic receptor

• M1/M3

• M2/M4

Gi

• alpha 2 adrenergic receptor

• M1/M3

• M2/M4