NEU335 10/5/23 Review Session

According to the chemoaffinity hypothesis, axons are guided to their targets by:

• Electrical signals

• Complementary chemical markers

• Magnetic fields

• Mechanical cues

In Sperry's experiments, what happened when half of the retinal ganglion cells (RGCs) were removed and the other half were allowed to grow back?

• RGCs failed to reconnect with specific target sites

• RGCs connected randomly to the brain

• RGCs reconnected with specific target sites

• RGCs failed to grow back at all

The repellant found in the posterior tectum that affects temporal retinal axons is identified as:

• Ephrin-B3

• Ephrin-A5

• Eph receptor

• Neurofascin

What is the role of neurofascin in axonal targeting?

• Neurofascin serves as a repellant for axons

• Neurofascin promotes axon growth

• Neurofascin guides axons to their postsynaptic targets

• Neurofascin is involved in synapse formation

The process of programmed cell death is known as:

• Necrosis

• Apoptosis

• Synaptogenesis

• Dendritogenesis

What do neurotrophins do to support neuronal survival?

• They induce apoptosis in neurons

• They directly stimulate the growth of connections

• They shut off the genetic program for cell death

• They promote inflammation in neurons

The first trophic factor to be identified was:

• NGF

• BDNF

• NT-3

• NT-4

Which receptors are primarily activated by neurotrophins?

• GABA receptors

• NMDA receptors

• trk receptors

• AMPA receptors

Necrosis is characterized by:

• Programmed cell death

• Accidental cell injury

• Genetic instructions for cell death

• Apoptotic signaling

Apoptosis involves:

• Cells splitting open and pouring contents into extracellular space

• Genetically programmed cell death

• Inducing inflammatory responses

• Accidental cell injury