Chromosomal Mutation

What is a chromosomal mutation?

• A mutation that affects a single gene.

• A mutation that alters the structure or number of chromosomes.

• A mutation caused by exposure to radiation.

• A mutation that occurs only in gametes.

Which of the following best describes a chromosomal deletion?

• A chromosome segment is reversed.

• An extra copy of a chromosome segment is present.

• A chromosome segment is removed.

• Two chromosomes exchange segments.

Which chromosomal mutation involves the reversal of a chromosome segment?

• Deletion

• Inversion

• Duplication

• Translocation

If a chromosome experiences a duplication mutation, what happens?

• A chromosome segment is lost.

• A chromosome segment is repeated, creating an extra copy.

• Two chromosomes swap segments.

• Chromosomes fuse together.

What is translocation in terms of chromosomal mutations?

• A chromosome segment is removed.

• Two chromosomes exchange segments.

• A chromosome segment is repeated.

• An entire chromosome is duplicated.

Which of the following genetic disorders is caused by chromosomal deletion?

• Down syndrome (Trisomy 21)

• Turner syndrome (Monosomy X)

• Cri-du-chat syndrome

• Chronic Myelogenous Leukemia (CML)

Aneuploidy is a type of chromosomal mutation that involves:

i. The addition of an extra chromosome.

ii. The removal of a chromosome.

iii. An abnormal number of chromosomes in a cell.

iv. The inversion of a chromosome segment.

• i, ii

• ii, iii, iv

• iii, iv

• i, ii, iii

What is the potential consequence of a chromosomal translocation involving two non-homologous chromosomes?

• No impact on gene expression or phenotype.

• Increased genetic diversity.

• Altered gene expression and potential health issues.

• Improved genetic stability.