Anesthesia pharmacology/pharmacokinetics

Where is the action site for local anesthetics?

• The K+ receptors in the K+ channels

• All along the nerve membrane

• The structural proteins known as specific gate receptors in the K+ channels

• The structural proteins known as specific gate receptors in the Na+ channels

Which type of local anesthetics are no longer inject-able due to their high rate of allergic reactions?

• amides

• esters

Which of the following anesthetics will provide the most rapid onset based on its pKa?

• Mepivacaine

• Lidocaine

• Bupivacaine

• Benzocaine

The dissociation constant (pKa) of an anesthetic predicts the proportion of the molecules that exist in the acid form verses the base form. The pKa affects quickness of onset.

• Both statements are true

• Both statements are false

• 1st true. 2nd false

• 1st false. second true.

After dissociation of the local anesthetic tail, the base form (RN) serves what purpose?

• Blocks the sodium channel gate

• Passes through the nerve membrane

• Is not involved in the process

• High level of cation molecules

How does the tissue pH affect the action of local anesthetics?

• Lower pH increases potency

• Higher pH increases potency

• pH has no effect on potency

• pH affects duration, not potency

Which local anesthetic is associated with a higher risk of allergic reactions?

• Lidocaine

• Bupivacaine

• Mepivacaine

• Articaine

Storm had a good British accent last week

• False

• True

The potency of an anesthetic is primarily a result of its...

• Water solubility

• Protein solubility

• Lipid solubility

• carbohydrate solubility