Ryzodeg Quiz May 2024

1.  Co-formulation of a basal insulin with a bolus insulin in a single injection would NOT:

• mimic physiological insulin profile more closely

• void the shoulder effect

• avoid variability of protaminated premixed insulins

• increase Injection burden

The coformulation IDegAsp was feasible because

• Insulin aspart hexamers interact with insulin degludec multihexamer in subcutaneous space

• Formation of stable dihexamers of insulin degludec in solution, which do not interact with insulin aspart molecules

• Insulin degludec forms dihexamers in subcutaneous space

• Insulin degludec and insulin aspart form hybrid hexamers

Upon injection ___________ diffuses rapidly and change the conformation of dihexamers of insulin degludec to link together via side-chain contacts to assemble in long multihexamer chains.

• 1. Zinc

• 1. Chlorine

• 1. Phenol

• 1. Glutamic acid

At the time of diagnosis of Type 1 Diabetes, approximately _____ % of Beta cells are lost

• 30-40%

• 50-60%

• 60-70%

• 85-95% 

The mean half life of Insulin Degludec is longer than ___________ hours.

• 12

• 18

• 25

• 19

According to Step by step trial,

• non inferiority of HbA1c

• Superiority of HbA1c control

• Inferiority was confirmed

• none of the above

Total daily dose of Step by step trial showed

a. Significantly decreased

b. Same

c. comparable results

a

• Significantly decreased

• Same dose

• Non inferiority was confirmed

• None of the above

According to Step-by-step trial, confirmed hypoglycemia was ___ %

• 14% lower lower at week 26

• 10% lower at week 38

• 14% lower at week 26

• 14% lower at week 38

In Arise Trial over all HbA1c drop was seen as

• -2%

• -1.2%

• -2.2%

• -1.4%

Weight reduction is due to (In accordance with ARISE Trial)

• Insulin Degludeg directly

• avoidance of patient's compensation meal eating habit in fear of hypoglycaemia

• due to the prolonged half life of Insulin co formulation

• None