Toxicology Review

A low LD50 indicates...

• a low toxicity

• that 50 mg can be ingested without harm to humans

• a high toxicity

• that 50% of the time ingestion causes death

Bioassays can be performed on which of the following substances?

• pesticides

• nutrients

• food products

• all of these choices

Who took the largest dose of ibuprofen?

• An adult woman who weighs 150lb and took 300 mg of ibuprofen?

• A baby who weighs 20lb and took 100mg of ibuprofen.

• A chihuahua that weighs 5lb and took 50mg of ibuprofen.

• A teenage boy who weighs 135lb and took 600mg of ibuprofen.

What is the LD50 of the drug shown?

• 10 mg

• 15 mg

• 25 mg

• 35 mg

The therapeutic index is calculated by

• LD50/ED50

• ED50/TD50

• TD50/LD50

• TD50/ED50

What is the unit of a therapeutic index?

• mg

• kg

• mg/kg

• none

Which drug is less potent?

• Drug A

• Drug B

• they have the same potency

• Not enough information

Based on the ED50 curves shown, which drug is the most effective?

• Drug A

• Drug B

• Drug C

• Drug D

Based on the data provided, which route of exposure is the most dangerous?

• oral

• dermal

• inhalation

• none of the above

On a standard bioassay curve, what is measured on the X-axis?

• The effect of the substance tested

• The number of specimens tested

• The concentration of the substance tested

• The types of organisms tested