BIO 30_Lec 6_Handout A

(1953) He proposed the need for a genetic codiing system but his proposed system didn't work.

• George Gamow
• Francis Crick
• Marianne Grunberg, Manago and Severo Ochoa
• Marshall Nirenberg and Johann Heinrich Matthaei

He saw the need for a genetic coding system

• George Gamow
• Francis Crick
• Marianne Grunberg, Manago and Severo Ochoa
• Marshall Nirenberg and Johann Heinrich Matthaei

Made synthetic RNAs using polynucleotide phosphorylase. CTP = Poly C GTP = Poly G ATP = Poly A UTP = Poly U

• George Gamow
• Francis Crick
• Marianne Grunberg, Manago and Severo Ochoa
• Marshall Nirenberg and Johann Heinrich Matthaei

Produced artificial mRNA and introduced into a cell free system, by controlling the amount of U and G, they predicted the amounts of codon within the random polymer

• George Gamow
• Francis Crick
• Marianne Grunberg, Manago and Severo Ochoa
• Marshall Nirenberg and Johann Heinrich Matthaei

It was already known that extracts from bacterial cells were able to synthesize polypeptides. Proteins were specified by the mRNA in the extract

• True (/)
• False (x)
• Cannot be determined

Predict the amount of codons if the amount of U is 30% while G is 70%. GGG

• 0.34
• 0.15
• 0.06
• 0.03

Predict the amount of codons if the amount of U is 30% while G is 70%. GGU

• 0.34
• 0.15
• 0.06
• 0.03

Predict the amount of codons if the amount of U is 30% while G is 70%. GUU

• 0.34
• 0.15
• 0.06
• 0.03

Predict the amount of codons if the amount of U is 30% while G is 70%. UUU

• 0.34
• 0.15
• 0.06
• 0.03