renal final ( tubule interstitial disease)

common causes of acute interstitial nephritis

• Drugs

  infections

  systemic diseases

  idiopathic causes

• Antiviral agents

  Anticonvulsants

  other agents

  Muerte

The primary pathogenic mechanism of interstitum in the drug induced nephritis is:

• Type IV Hypersensitive reactions

• TypeIII

  Hypersensitive

• Type 1

  Hypersensitive

• Lymphocytic interstitial and peritubular infiltrate

• Tabulates

• Tubulitis

• Lymphocytic interstitial and peritubular infiltrate

• Tubulitis Diffuse inflamatorio infiltrate

• Immunofluorescence

• tubulitis Diffuse inflammatory infiltrate

• Acute tubular Necrosis

The most common intrinsic cause of acute kidney injury is;

• Acute tubular necrosis

• Ischemia

• toxins or sepsis

The pattern of injury

that defines acute tubular necrosis includes:

• Tubular cell damage + death

• Ischemic Type and Toxic Type

Any factors that leads to pre renal azotemia can lead ti ischemic acute tubular.

• sepsis or anaphylaxis

• Edematous states and heart failure

• Hypovolemic states.

  diarrhea

  vomiting

  bleeding

  dehydration

  burns

Acute tubular necrosis is precipitated by:

• severe ischemic and toxic events or sepsis

• Acute ischemic and toxic event or sepsis

• ischemic and toxic event or sepsis.

Edematous states such as heart failure and cirrhosis cause:

• Kidney perfusion

• heme pigment

• crystal induced.