Meiosis

PGCs are undifferentiated stem cells that eventually give us what type of cells?

• Muscle

• Somatic

• Hepatic

• Oocyte

Oct4 does what?

• Induce telomere growth

• Induce spermatogenesis

• Promote migration of a specific precursor cell

• Endocrine stress signaling

What is the difference between Sertoli cells and Leydig cells?

• Sertoli Cells produce oocytes whereas Leydig cells produce lutenizing hormone

• Sertoli cells produce testosterone whereas Leydig cells produce estrogen

• Sertoli cells produce sperm and Leydig cells produce testosterone

• Sertoli cells are another name for Theca cells and produce estrogen, whereas Leydig cells are another name for Granulosa cells and produce oocytes

In oogenesis, meiosis 1 is completed __ while meiosis 2 is completed _

• prior to ovulation, after fertilization

• prior to fertilization, after ovulation

• by the spermatozoa; after fertilization

You are provided with a histological sample of ovarian tissue from an XX 11 year old. What are the ploidy states you expect to observe on the slide?

• 2n

• 2n, 4n

• 1n, 2n, 4n

• 1n, 2n

Which is a unique characteristic of metaphase in meiosis 1?

• Presence of chiasmatic centers

• Miotic spindle formation

• Nuclear degredation

• Lining-up of homologous chromosomes

The synaptonemal complex does what?

• Binds the kinecticore to chromosomes in meiosis 2

• Deprotonates the 3' Telomere to cause chromosomal unwinding for crossing-over

• Connects the two homologous chromosomes in meiosis 1

• Inhibits m-CDK/Cyclin to halt oocyte meiosis in anaphase I

What does a nondisjunction event cause in meiosis I

• 50% chance of trisomy, 50% chance of aneuploidy

• 25% chance of trisomy, 50% chance of normal offspring, 25% chance of aneuploidy

• 50% chance normal offspring, 50% chance aneuploidy

• 25% chance trisomy, 50% chance monoploidy, 25% chance normal off spring

If an individual expresses TFIID without Taf4b, what would we expect to observe?

• Decreased levels of Follicle stimulating hormone

• Asynapsis of the chromosomes in meiosis I

• Fertility is elongated

• osteoperosis