BIO 30_Lec 5_DNA Importance, Events, and Scientists

In 1830s, it was regarded as the most important molecules.

Greek for "of first importance"

Scientist that stated 6 characteristics of genetic material (slide)

1860s, while characterizing proteins from pus cells, a molecule different from protein was isolated from the nucleus and called it "nuclein" (DNA)

• Fredrich Miescher

• Earnst Haeckel

• Edmund Wilson

• Fredrerick Griffith

1866, discovered that the most obvious cellular component of a cell was nucleus

• Earnst Haeckel

• Fredrich Miescher

• Edmund Wilson

• Fredrerick Griffith

1895, using staining technique, he discovered that the most important nuclear element handed from cell to cell was the DNA. Observed through the karyokinesis of ovum.

• Edmund Wilson

• Fredrich Miescher

• Earnst Haeckel

• Fredrerick Griffith

1928, US Medical Officer did transformation experiment (on mouse) using Streptococcus pneumoniae and declared the presence of *transforming principle*. (Rough->Smooth)

• Fredrerick Griffith

• Fredrich Miescher

• Earnst Haeckel

• Edmund Wilson

1928 Experiment where heat killed virulent S + regular avirulent R cells into mice = death of mice

• Transformation Experiment
• Blender Experiment
• Transduction Experiment

1930s, _._. _____, a quantitative geneticist stated two points about genes:

1. Hypothetical Entity

2. Chemical compound

1944, Transforming Principle (TP) was DNA. DNA treatment under protein and RNA enzyme = ability retained. DNA treated under DNA enzyme = ability lost.

• Oswald Avery, Colin Macleod, and Maclyn McCarthy
• Alfred Hershey & Martha Chase
• Norton Zinder, Joshua and Esther Lederberg
• Rosalind Franklin, Maurice Wilkins, James Watson, and Francis Crick