Chapter 19

The distinct series of changes that characterizes programmed cell death is called

• necrosis

• apoptosis

• sepsis

• execution

During development, 50% of neurons die; those that survive are those that

• generated axons

• received epithelial growth factor

• made correct connections with their target cells

• did not receive an extracellular cell death signal

Which of the following events is not part of apoptosis?

• fragmenting of chromosomal DNA

• fragmenting of the nucleus

• fragmenting of the cell

• lysis of cell fragments and release of their contents

Cells that die as the result of acute injury undergo

• lysis

• sepsis

• apoptosis

• execution

Apoptotic cells produce “eat me” signals, which include _______ of cell surface _______.

• loss; carbohydrates

• loss; phosphatidylserines

• gain; phosphatidylserines

• gain; phosphatidylethanolamines

The gene ced-3 of C. elegans codes for a proteolytic enzyme that is a

• serine protease

• chymotrypsin

• ubiquitin-targeted protease

• caspase

Ced-9 functions directly to

• inhibit Ced-3

• inhibit Ced-4

• stimulate Ced-3

• stimulate Ced-4

An apoptosome is a complex containing multiple subunits of

• Apaf-1

• Apaf-1 and caspase-9

• Apaf-1 and caspase-3

• Apaf-1, caspase-9, and cytochrome c

Effector caspases cleave

• nuclear lamins

• cytoskeletal proteins

• DNase inhibitor

• All of the above

Members of the Bcl-2 family of proteins are

• all caspases

• either antiapoptotic or proapoptotic

• all antiapoptotic

• all proapoptotic