Exam 4 chemistry

Which of the following statements about lispro (insulin analogue) is correct?

• A lysine-proline sequence at the end of the insulin A chain reversed

• A lysine-Arginine sequence at the end of the insulin B chain reversed

• A lysine-Arginine sequence at the end of the insulin A chain reversed

• A lysine-Alanine sequence at the end of the insulin B chain reversed

• A lysine-proline sequence at the end of the insulin B chain reversed

Which of the following statements about Lispro (Insulin analog) is/are correct?

• A lysine-Proline sequence at the end of the insulin B chain reversed

• Lispro is Long-acting insulin analog

• Lispro differs from human insulin in the replacement of the B3 amino acid asparagine with lysine

• Lispro is a Rapid-acting insulin analog

• Lispro prepared by N-acylation of the LysB29 with the 14-carbon myristic acid

Which of the following insulin analogues is/are rapid-acting analogs?

• Insulin glargine

• Insulin detemir

• Glulisine

• Insulin Ultralente

• Insulin-protamine complex

Which of the following insulin analog contains myristic acid (Fatty acid)?

• Insulin glargine

• Lyspro

• Insulin detemir

• Glulisine

• Ultralente insulin

Which of the following insulin preparation contains Zn2+?

• Insulin glargine

• Lyspro

• Insulin-protamine complex

• Glulisine

• Ultralente insulin

Which of the following statements about insulin glargine is correct?

• Two extra arginine molecules attached at the end of the B chain to increase the isoelectric point

• Two extra arginine molecules attached at the end of the B chain to increase the acidity

• Two extra arginine molecules attached at the end of the B chain to increase the lipophilicity

• Two extra arginine molecules attached at the end of the B chain to promote albumin binding

• Two extra arginine molecules attached at the end of the B chain to decrease the isoelectric point

Which of the following statement about insulin aspart is/are correct?

SATA

• Aspart is a Rapid-acting insulin analog

• Insulin aspart incorporates an amino-acid change (Pro B28 to Asp) that also creates charge repulsion

• Aspart is a long-acting insulin analog

• Aspart differs from human insulin in the replacement of B3 amino aid asparagine with lysine

Which of the following compounds is to stimulate the release of insulin from beta cells?

• Biguanide

• Sulfonylureas

• Insulin detemir

• Ultralente insulin

Which of the following compounds is to insulin sensitizer (enhance insulin sensitivity)?

• Biguanide

• Sulfonylureas

• Insulin detemir

• Ultralente insulin

Which of the following compounds inhibits alpha-glucosidase?

• Biguanide

• Sulfonylureas

• Insulin detemir

• Ultralente insulin

• Acarbose