Test14 aln

B-ALL findings

​ (a)   relationship between ​ (b)   and age.

Poorer outcomes: ​ (c)   at diagnosis,​ (d)   WBC at diagnosis, ​ (e)   karyotype

• Inverse
• prognosis
• <1y/o
• high
• complex
• low
• >1 y/o
• Reverse
• diagnosis
• compound

This type Includes leukemias in which the morphology, cytochemistry and immunophenotype of blasts cannot determine lineage as myeloid or lymphoid.

• Chronic Lymphoid Leukemia (CLL)

• Acute Lymphoid Leukemia (ALL)                       

• Acute Undifferentiated Leukemia (AUL)

• Terminal Deoxynucleotidyl Transferase (TdT)

AUL findings

​ (a)   may be done to ​ (b)   evidence of primary granules

​ (c)   cytometry ​ (d)   may be performed

• Electron microscopy
• detect
• Extensive flow
• panels

AUL continued

Predominantly diagnosed in ​ (a)  

Only ​ (b)   of patients ​ (c)   to treatments for ​ (d)  

• adults
• ~1/3
• respond
• AML and ALL
• cured during

T-ALL findings

Very ​ (a)   WBC count

“​ (b)   ” in PAS staining

Blasts more likely to be ​ (c)   in size or have ​ (d)  

​ (e)   for TdT, CD3 and CD7

• high
• Chunky positivity
• variable
• vacuoles
• Positive
• negative
• angular positivity
• stable
• low

Which of these is not a finding of T-ALL?

• Discolored or deformed teeth and/or gums

• various cytogenetic abnormalities identified

• prognosis not as good as B-ALL

• better prognosis in adults than in children

Leukemias in which blasts have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells OR and both B and T lymphocytes.

• Acute Leukemias with Lineage Heterogeneity

• Lymphoid stem cell (CLP)

• Lymphopoiesis

• Prolymphocyte

Which of these are the two distinct populations of blasts identifiable in Bi-lineage acute leukemia?

• two B, and five T

• one myeloid, one lymphoid OR

• One B, one T

• two myeloid, one lymphoid OR

Which of these express Bi-phenotypic acute leukemia with one population having 2 different markers?

• blasts co-express myeloid and lymphoid markers

• one myeloid, one lymphoid OR

• One B, one T

• blasts co-express B and T markers

Which of these is NOT an immature lymphoid neoplasm? Choose all that apply.

• Acute lymphoblastic leukemia (ALL)

• Malignant lymphomas

• Chronic lymphoid leukemias

• Lymphoblastic lymphoma