Which of the following statements correctly defines autoimmunity?

IS le 4

Quiz
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Biology
•
University
•
Easy
Mary Rosette
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50 questions
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1.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
Increase of tolerance to self-antigens and subsequent formation of autoantibodies
Loss of tolerance to self-antigens
Increase in clonal deletion of mutant cells
Manifestation of immunosuppression
2.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
What disease is indicated by a high titer of anti-Sm (anti-Smith) antibody?
Mixed connective tissue disease
Rheumatoid arthritis
Systemic Lupus Erythematosus
Scleroderma
3.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
Which of the following is true about the factors influencing development to autoimmunity?
Autoimmune disorders and autoantibodies are found more frequently in men than women
Human leukocyte antigens are associated with decreased risk of autoimmune states
The incidence of autoantibodies decreases steadily with age due to decreased immune status of the elderly
Ultraviolet radiation, viruses, and chronic infectious disease may play a role in the development of autoimmune disorders
4.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
Which statement is not true about central tolerance?
The process of eliminating any developing T or B lymphocytes that are reactive to self
A process involving mature lymphocytes and occurs in the circulation / immune periphery
Also known as negative selection
Develops in the thymus during fetal life
5.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
In celiac disease, key laboratory diagnostic assays comprise testing for
autoantibodies against tissue transglutaminase (anti-tTG)
endomysium (EmA) antibodies against deamidated gliadin peptides
celiac disease (CD)-associated human leukocyte antigens (HLA) DQ2 and DQ8
All are correct
6.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
Antibodies to thyroid peroxidase can be detected by using agglutination assays. Which of the following diseases may show positive results with this type of assay?
Myasthenia gravis
Granulomatous thyroid disease
Graves’ disease and Hashimoto’s thyroiditis
Addison’s disease
7.
MULTIPLE CHOICE QUESTION
10 mins • 1 pt
Which statement explains the pathogenesis of Rheumatoid Arthritis?
elevated titers of anti-dsDNA and anti–ribosomal P antibodies, as well as reduced levels of complement and leukopenia
loss of tolerance to nuclear antigens with deposition of immune complexes in tissues and associated multiorgan involvement
presence of acetylcholine receptor-blocking antibodies
an infective agent or other stimulus binds to receptors on dendritic cells which then activates the innate immune system
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