M&R Session 6

What is pharmacokinetics?

• describes what a drug does to the body

• describes what the body does to a drug

• time taken for the plasma concentration of a drug to reduce to half its original value

What are the pharmacodynamics of inhaled salbutamol?

• 10-25% is distributed to the lung. The swallowed portion is absorbed from the gastrointestinal tract and undergoes considerable first-pass metabolism.

• It is a ß 2-adrenergic receptor antagonist

• It is a selective ß 2-adrenergic receptor agonist

• White odourless powder intended for respiratory use by oral inhalation

True or False:

Drugs which mimic endogenous ligands activating receptors and lead to a response are called agonists

• True

• False

Fill in the blank:

Morphine is an opioid receptor ________ – its main effect is binding to and activating opioid receptors in the central nervous system.

• Agonist

• Antagonist

What is meant by the efficacy of a drug?

• The amount of drug necessary to produce a certain response

• The tendency of a drug to bind to a specific receptor

• The strength of response caused by drug when it interacts with a receptor