2&3. Neuronal and Receptor Physiology

•There is 2 way passage of proteins, organelles & other materials along axon of neuron called as ________________

• Axonal transport

• Somal transport

•@20-400mm/day

•Both AG & RG directions

•Certain viruses & toxins can be conveyed by axonal transport along peripheral nerves e.g. chickenpox, tetanus

• Fast Axonal transport

• Slow Axonal transport

•@0.5-10mm/day

•Always anterograde

•Moves enzymes & cytoskeletal components

• Fast Axonal transport

• Slow Axonal transport

•Axonal transmission occurs through rapid, sudden, rise change in membrane potential known as _______________________ (once it is generated always propagates)

• Action Potential

• Reaction Potential

•Properties of Action Potential

• •Threshold level

• •Refractory period

• •Conductivity (ability of neuron to carry +ve charges laterally which is stimulus for another AP) referred as cable property.

• •Propagation

•Neuronal growth factors or

•Chemicals that promote neuronal growth in the fetal brain

•THESE INCLUDE:

1. Nerve growth factor (NGF)

2. Brain derived neurotrophic factor (BDNF) &

3. Glial derived neurotrophic factor (GDNF)

• Neurotrophins

• Synapse

•Specialized junction where transfer of information takes place between a neuron and a target cell

•Target cell can be another neuron, muscle, cell, or gland

•____________means clasping of hand as in

•HAND SHAKE

• Neurotrophins

• Synapse

•Common

•Axon terminal & dendrite

• Axo dendritic

• Axo somatic

• Axo axonic

• Chemical Synapse

• Electrical synapse

•Axon & cell body

• Axo dendritic

• Axo somatic

• Axo axonic

• Chemical Synapse

• Electrical synapse

•Less common

•Axon &Axon

• Axo dendritic

• Axo somatic

• Axo axonic

• Chemical Synapse

• Electrical synapse