Extracellular Matrix

1.      Which of the following is NOT component of the extracellular matrix?

• Collagen

• Elastin

• Fibronectin

• Keratin

------is the only amino acid small enough to be accommodated in the limited space available in the central core of the triple helix.

Fibronectin and laminin are examples of

----- is an unbranched polysaccharide made up of repeating disaccharides, one component of which is always an amino sugar either D-glucosamine or D-galactosamine

---- is a major component of most connective tissues, constitutes approximately 25% of the protein of mammals

Collagen fibers are further stabilized by the formation of______

​ ​ (a)   affects the structure of collagen. However, it is due to a deficiency of ​ (b)  

• Scurvey
• Vitamin C

Deficiency of copper results in defective cross-linking of collagen and elastin by the copper-dependent enzyme lysyl l oxidase.​ ​ ​ (a)  

• Menkes disease
• Scurvey
• Aports disease
• Alports disease

---are proteins that contain covalently linked Glycosaminoglycan

The amino acid replaces glycine in collagen's primary structure in osteogenesis imperfecta​ ​ (a)  

• Valine
• Glutamic acid
• Lysine