hemoglobinopathies/thalassemiasp1

Which of these is not a qualitative Disorder of hemobloniopathies?

• Result of inherited genetic mutations in which amino acid substitutions or deletions cause structural changes in globin chains of the Hgb molecule

• Altered amino acid sequence causes globin chains to behave differently—structurally, electrochemically, and functionally

• Causes an imbalance between “partner” chains

• Structurally abnormal Hgb may cause a wide range of clinical features, from none at all to life-threatening symptoms.

Tags

NGSS.HS-LS3-2

NGSS.HS-LS1-1

Which of these is NOT a Quantitative disorder of Thalassemias?

• Named according to decreased chain

  Alpha Thalassemia

  Beta Thalassemia

• Causes an imbalance between “partner” chains

• Result of various genetic defects that cause decreased synthesis of normal globin chains

• Altered amino acid sequence causes globin chains to behave differently—structurally, electrochemically, and functionally

Tags

NGSS.HS-LS3-2

NGSS.HS-LS1-1

1 Hgb = ​ (a)   rings

    + ​ (b)   chains

    + 4 ​ (c)   atoms

1 hemoglobin

  ​ (d)  

  molecules

• 4 porphyrin
• 4 globin
• iron
• carries 4 O2

Match the correct label to the Hemoglobin Molecule.

a

b

c

d

e

Heme

Tags

NGSS.HS-LS1-6

Which of these is NOT Defective globin synthesis in HGB production? Choose all that apply.

• Thalassemias

• Hemoglobinopathies

• Iron deficiency anemia (IDA)

• Siderblastic anemia (SA)

Tags

NGSS.HS-LS3-2

Which of these is NOT a defective heme synthesis in HGB production?

• Thalassemias

• Iron Deficiency anemia (IDA)

• Anemia of chronic disease (ACD)/Anemia of inflammation (AOI)

• Sideroblastic anemia (SA)

Place each word correctly on the HGB production.

a

b

c

d

e

f

g

h

i

Globin gene mutations

IDA ACD

EPO

ACD

SA porphyrias

Heme enzymes

iron

Cytokines

Thalassemia

Complete the diagram.

d

a

b

c

e

f

g

Hemoglobinopathies

disturbed

Hemoglobin

or deletions

abnormal

Globin

Heme

Tags

NGSS.HS-LS3-2

Match the following

• chromosome 11

• Hgb F

• Alpha genes

• chromosome 16

• Hgb A₂

• Hgb A

• Beta, delta, gamma genes

Match the following

• Beta, delta, gamma genes

• chromosome 16

• 2%

• 2.5%

• 97%

• Alpha genes

• chromosome 11

Tags

NGSS.HS-LS3-1