Stereochemistry Quiz!

Chirality...

• ... is a property of a molecule, not a mixture

• ... can be quantified by measuring optical rotation

• ... requires a molecule with a chiral centre

• ... can only be observed at a molecular level

How can you prove if a novel enantiopure compound has R or S configuration?

• Derivatising (e.g. Mosher's ester) then 1H NMR

• Measuring [α]_D

• Chiral HPLC

• X-ray crystallography

How many possible stereoisomers does Baulamycin have? (7 stereocentres)

• 7

• 14

• 49

• 128

How many possible stereoisomers does tartaric acid have?

• 1

• 2

• 3

• 4

Two enantiomers will have the same...

• IC₅₀

• Solubility

• Microsomal clearance

• In vivo PK

This reaction is...

• Asymmetric

• Stereospecific

• Stereoselective

• None of the above

What is the difference between a chiral ligand and a chiral auxiliary?

• The chiral auxiliary is made from the chiral pool

• The chiral ligand is used catalytically

• The chiral auxiliary is covalently bound to the starting material

• None are correct