Genetics Lecture 2: Colorectal Cancer

Majority of colon cancers are

• sporadic

• familial

benign adenomatous growths protruding from the mucous membrane of the colon and rectum

• polyps

• tumors

• lesions

Which of the following are true?

• The US Preventive Services Task Force (USPSTF) recommends that adults 45-75 be screened for colorectal cancer

• The decision to be screened after the age of 75 should be made on an individual basis

• The US Preventive Services Task Force (USPSTF) recommends that adults 30-60 be screened for colorectal cancer

• The decision to be screened after the age of 60 should be made on an individual basis

-Gene termed APC

-Adenomas start as polyps, many form

-Can progress to malignancy

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)

-Disease termed _____ or Lynch Syndrome

-Many fewer polyps

-Other tumors also common

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)

autosomal dominant

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)

APC

• oncogene

• tumor suppressor gene

Also known as Lynch Syndrome

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)

develop only a few adenomas, usually affecting the right side of the colon

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)

Amsterdam criteria II is used for diagnosis

• Familial Adenomatous Polyposis Coli (FAP)

• Hereditary Non-Polyposis Colon Cancer (HNPCC)