Lyrica

These are the therapeutic indications of Lyrica, except ________.

• Neuropathic Pain

• Epilepsy

• GAD

• Fibromyalgia

• Nociceptive Pain

In patients with fibromyalgia, the usual dose range for most patients is 300 mg to 450 mg per day given in two divided doses. Some patients may derive additional benefit at 600 mg per day.

• True

• False

Pregabalin oral bioavailability is estimated to be ______ and is independent of dose.

• > 98%

• > 90%

• < 90%

• > 97%

Following repeated administration, steady state is achieved within 24-48 hours.

• True

• False

Elimination half-life of Pregabalin

• 5 hours

• 7 hours

• 6.3 hours

• 8.3 hours

Starting dose and maximum dose for patients with creatinine clearance of > 60.

• 75 mg - 300 mg

• 50 mg- 150 mg

• 150 mg- 600 mg

• 25mg - 50 mg

Pregabalin is recommended for pediatric patients ages 12 years old and above.

• False

• True

Because renal elimination is the major elimination pathway, dosage reduction in patients with renal impairment and dosage supplementation following hemodialysis is necessary.

• True

• False

Dosage of Pregabalin used in the study of Taguchi et al in Japanese patients?

• 75 mg- 300 mg

• 25 mg - 300 mg

• 50 mg- 300 mg

• 150 mg - 600 mg

Dosage adjustment is required for patients with severe hepatic impairment.

• True

• False