Powders & Granules

Which of the following statements describe the powder dosage form? (you may choose more than one answer)

• The diameter of the particles is less than 1000 um

• The dosage form composed of solid and dry particles in aggregated form

• The dosage form may contain one or more active ingredient(s)

• The dosage form can be prepared via granulation process

Which of the following statements are TRUE regarding the granulation process? (you may choose more than one answer)

• Granulation can reduce high surface energy of small particles, improving the powder flow

• Binder used in the granulation process may prevent compaction of the powder into tablets

• Granulation can prevent small particles of drug powder from being separated towards the upper part of a powder mix

• Granulation will allow small amount of moisture to be absorbed by the powder while maintaining its good flowability

Which of the following granules cannot control the release of drug/active ingredients?

• Coated granules

• Effervescent granules

• Modified-release granules

• Gastro-resistant granules

High number of blood vessels in the nasal cavity allows the absorption of drug from nasal powders for systemic absorption?

• True

• False

Mixing using plastic bag method involves filling a plastic bag until full with a powder mix, prior to sealing and shaking the plastic bag.

• True

• False

Which of the following statements regarding the dissolution rate of solid dosage forms is/are CORRECT? (you may choose more than one answer)

• Powders will have a slower dissolution rate compared to tablet.

• Tablet will have an immediate dissolution after a patient swallow the dosage form.

• The capsule shell will need to be dissolved first prior to the release and dissolution of the powders inside the dosage form.