Kuis Mentoring DM

Which of the following is not auto-antibodies is a marker for type 1 diabetes ?

• Antibodies to GAD-65

• Antibodies to tyrosine phosphatase IA-2 and IA-2 beta

• Zinc transporter 8 (ZnT8)

• Anti muscle-specific tyrosine kinase (MuSK)

Which of the following are the characteristic features of type 1 diabetes mellitus ?

• Caused by an absolute deficiency of insulin

• Associated with autoimmune destruction of beta cells

• Presents with diabetic ketoacidosis

• All of above

Prediabetes is the the term used for individuals that do not meet the criteria for diabetes but are too high to be considered normal. Which of the following statement accurately characterize prediabetes ?

• Fasting blood glucose from 120 -180 mg/dL

• Fasting blood glucose from 126 - 140 mg/dL

• Fasting blood glucose from 100 -125 mg/dL

• All of above

Sulphonylureas increase insulin secretion by beta cells. Sulphonylurea acts by binding sulphonylurea receptor and inhibit...

• ATP dependent K+ channel

• Voltage-gated calcium channel

• GLUT-2

• None of above

Glitazone is an oral hypoglycemic drug used to treat hyperglycemia. Which of the following is not correct regarding the mechanism of action of Glitazones

• Glitazone binds to the peroxisome proliferating activator receptor gamma

• Peroxisome-proliferating activator receptor-gamma is a cell surface receptor found in adipocytes

• Glitazone increases insulin sensitivity

• Increase glucose uptake in muscle and fat

Which is of the following is not the consequence of insulin deficiency in carbohydrate metabolism?

• Increased blood glucose concentration

• Increased glycogen breakdown

• Decreased peripheral glucose utilization

• Decreased gluconeogenesis

The acute complications of uncontrolled diabetes mellitus include hyperosmolar coma, diabetic ketoacidosis, etc. Which of the following statement is false regarding the hyperglycemia hyperosmolar coma?

• Severe hyperglycemia shifts fluid from the intracellular to the extracellular space

• Polyuria increases volume of extracellular space and decreased renal blood flow

• The severe loss of intracellular fluid from the brain causes the coma

• Decreased bicarbonate ion concentration

Among female children and adolescents, the first sign of type 1 diabetes may be:

• Rapid weight gain

• Constipation

• Genital candidiasis

• Insomnia

Which of the following diabetes drugs acts by decreasing the amount of glucose produced by the liver?

• Sulfonylureas

• Meglitinides

• Biguanides

• Alpha-glucosidase inhibitors

In Diabetic ketoacidosis, the lack of insulin causes increased production of ketone bodies. Which of the following laboratory results are likely seen in diabetic ketoacidosis

• Decreased arterial blood pH, increased blood glucose, decreased bicarbonate ion concentration

• Decreased arterial blood pH, increased blood glucose, decreased anion gap

• Increased arterial blood pH, increased blood glucose, decreased bicarbonate ion concentration

• Decreased arterial blood pH, increased blood glucose, increased bicarbonate ion concentration