Organization of Human Genome

Arrange the organization of genome in chronological order. What is the third state?

• DNA double helix

• Nucleosome fiber

• Solenoid

• Chromosome

• Chromatin

How many reading frames are available for reading in 5′→3′ direction?

The largest tandem repeats is Satellite DNA. The smallest tandem repeats is ______________ ___.

The fundamental unit of chromatin organization is ________

Which phase in cell cycle is the chromosome easiest to be distinguished and studied?

• Interphase

• Prophase

• Metaphase

• Anaphase

• Telophase

Name and distinguish the two types of heterochromatin.

Compared to nuclear genome, mitochondrial genome

• is larger in size

• has a greater number of conserved sequences

• owns a greater proportion of protein-coding genes

• has a greater proportion of heterochromatin

• is much less prone to mutation

What is the major goal in the post-genomic era after the achievement of Human Genome Project?

Which of the following does not belong to the achievements of the Human Genome Project?

• Constructed genetic map for facilitating genetic linkage studies

• Discovered nearly all human genes (protein-coding) to allow further study of human genetic diseases

• Developed simplified and automated technology for DNA sequencing

• Obtained complete sequence of pooled DNA extracted from cells donated by several anonymous donors

• Elucidation of the relationship between diseases (e.g. obesity, diabetes) and changes in the human microbiome