Journal Club

How many papers are the subject of today's JC?

• 0

• 1

• 2

• 3

Which one did you prefer?

• Lomakin

• Venturini

• I don't know

What's the common topic of those two papers?

• Endothelial cells

• Mechanosensing

• Migration

• Nucleus

What does the cell do in response to excessive compression?

Do the two papers find a similar mechanism?

• Yes

• No

• Don't know

When the nucleus is compressed, what happens to it?

• Its membrane unfolds

• It changes volume

• It gets stiffer

• Its membrane stretches

What does cPLA2 do?

• Interact with C3PO

• Requires Ca2+ to activate

• Inserts itself between lipids in stretched membranes

• Increases the production of arachidonic acid

What does the arachidonic acid do?

• Scares people

• Increases actin polymerization

• Increases myosin 2 activity through ATP

• Send people on acid trips

Myosin 2 activity is linked the contractility of the cortical actin network

• Yes

• No

• Don't know

• Can you repeat the question please?

The increased cortical tension leads to

• Blebbing

• Increased force on the AFM

• Increased cytosolic pressure

• Switch to amoeboid migration