CCC organic carbonyl reactions & more

Which of the following has 2 acidic hydrogens?

• I

• II

• III

• IV

Rank the molecules in order of increasing acidity (least acidic to most acidic).

• III, II, I

• II, III, I

• I, II, III

• II, I, III

• III, I, II

What is the order of decreasing reactivity towards nucleophilic acyl substitution for the carboxylic acid derivatives? (most reactive first)

• I, II, III, IV

• I, III, IV, II

• II, IV, III, I

• II, I, III, IV

• II, I, IV, III

What is the order of decreasing reactivity towards nucleophilic acyl substitution for the carboxylic acid derivatives? (most reactive first)

• I, III, II, IV

• I, III, IV, II

• II, IV, III, I

• II, I, III, IV

• IV, I, III, II

The purpose of the acid catalyst in the hydrolysis of an amide is:

• to enhance the nucleophilicity of the water molecule

• to shift the equilibrium of the reaction

• to enhance the electrophilicity of the water molecule

• to enhance the electrophilicity of the amide carbonyl carbon

The nucleophile in this reaction is _____.

• A

• B

• C

Compound C functions as _____ in this reaction

• a base scavenger

• a solvent

• a catalyst

• a neutralizer

Fischer esterification is an example of:

• nucleophilic acyl addition

• nucleophilic acyl substitution

• nucleophilic acyl elimination

• nucleophilic acyl rearrangement

Choose the best reagent(s) from the list provided below for carrying out the following transformation

• 1) CH₃MgBr, ether

  2.H₃O⁺

• 1) LiAlH₄, THF

  2.H₃O⁺

• 1. (Ph)₂CHMgBr

  2.H₃O⁺

• 1. PhMgBr, ether

  
  

  2.H₃O⁺

  
  

Choose the best reagent(s) from the list provided below for carrying out the following transformation

• 1) CH₃MgBr, ether

  2.H₃O⁺

• 1) LiAlH₄, THF

  2.H₃O⁺

• (Ph)2CHMgBr

  2.H₃O⁺

• (Ph)₂CuLi, ether